Chitosan-based polyelectrolyte complexes for drug delivery
نویسنده
چکیده
Among different polymers, chitosan, the N-deacetylated product of the polysaccharide chitin, is gaining increasing importance in medical and pharmaceutical applications due to its good mucoadhesion and absorption enhancing ability. Moreover, chitosan shows the ability to form hydrogels able to control the rate of drug release from the delivery system as well as protect the drug from chemical and enzymatic degradation in the administration site. In particular, when chitosan is cross-linked or complexed with an oppositely charged polyelectrolyte, a three-dimensional network is formed in which the drug can be incorporated in order to control its release.
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